In organic chemistry, the Bohlmann–Rahtz pyridine synthesis is a reaction that generates substituted pyridines in two steps, first a condensation reaction between an enamine and an ethynylketone to form an aminodiene intermediate, which after heat-induced E/Z isomerization undergoes a cyclodehydration to yield 2,3,6-trisubstituted pyridines.

References



Table 1 from Strategy for the synthesis of pyridazine heterocycles and

Solved 9.36 The BohlmannRahntz pyridine synthesis cyclizes

Solved E. In the Hantzsch synthesis, substituted pyridines

BohlmannRahtz Pyridine Synthesis

BohlmannRahtz Pyridine Synthesis